protein
| PTEN-interacting protein and negative regulator of PTEN in breast cancer |
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CXCL9 was involved in the invasion ability of hepatocellular carcinoma possibly through up-regulation of its potential effector PREX2 |
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guanine nucleotide exchange factor (GEF) for RAC1 GTPase, facilitating the exchange of GDP for GTP on RAC1 |
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RAC1 initiates its own inactivation by decreasing PREX2 GEF activity |
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reciprocal regulation of PREX2 by PTEN whereby loss of PTEN results in a dramatic increase in expression of PREX2 at the protein level |