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FLASH GENE
Symbol ALKBH5 contributors: mct - updated : 03-09-2016
HGNC name alkB, alkylation repair homolog 5 (E. coli)
HGNC id 25996
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a distinct "lid" region playing a vital role in substrate recognition and catalysis
  • a catalytic domain that can demethylate both single-stranded RNA and single-stranded DNA
  • secondary structure has a double-stranded beta-helix core fold as observed in other 2OG and iron-dependent oxygenase family members
    HOMOLOGY
    Homologene
    FAMILY
  • iron/ascorbate-dependent oxidoreductase family
  • AlkB family of dioxygenases
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • acting as an oxidoreductase
  • may have a role in the regulation of cellular responses to hypoxia
  • demethylase that oxidatively reverses N(6)-methyladenosine (m(6)A) in mRNA
  • 2-oxoglutarate (2OG) and ferrous iron-dependent nucleic acid oxygenase (NAOX) that catalyzes the demethylation of N(6)-methyladenine in RNA
  • plays a role in spermatogenesis
  • compared with other AlkB proteins, displays several unique structural features on top of the conserved double-stranded beta-helix fold typical of this protein family
  • ALKBH1, ALKBH5, ALKBH8 and FTO act as RNA demethylases
  • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Fe2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    METTL14, YTHDF3 and ALKBH5 were downregulated in Colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Alkbh5-deficient male mice have increased N(6)-methyladenosine (m(6)A) in mRNA and are characterized by impaired fertility resulting from apoptosis that affects meiotic metaphase-stage spermatocytes