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FLASH GENE
Symbol DEPDC5 contributors: mct - updated : 06-07-2014
HGNC name DEP domain containing 5
HGNC id 18423
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a DEP domain
HOMOLOGY
interspecies homolog to murine Depdc5 (94.3pc)
Homologene
FAMILY
CATEGORY signaling
SUBCELLULAR LOCALIZATION
basic FUNCTION unknown
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
  • DEPDC5, NPRL2 and NPRL3 are components of Gap Activity TOward Rags 1 (GATOR1), a complex involved in the inhibition of the mTOR complex 1 (MTOR)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FPEVF2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    with YWHAH, C22ORF24, in glioblastomas
    Susceptibility to hepatocellular carcinoma in chronic hepatitis C virus carriers
    Variant & Polymorphism SNP
  • intronic SNP in the DEPDC5 locus on chromosome 22 associated with hepatocellular carcinoma in chronic hepatitis C virus carriers
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS