Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol UHMK1 contributors: shn/npt - updated : 20-06-2015
HGNC name U2AF homology motif (UHM) kinase 1
HGNC id 19683
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RRM (RNA recognition motif) domain
  • a N-terminal serine/threonine kinase consensus region
  • a C-terminal region with homology to U2AF65
  • conjugated
    HOMOLOGY
    interspecies homolog to Uhmk1, Mus musculus
    homolog to Uhmk1, Rattus norvegicus
    homolog to UHMK1, Pan troglodytes
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text RNA granules
    basic FUNCTION
  • acting as a protein serine/threonine kinase
  • upon serum stimulation, phosphorylating CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase
  • may be involved in trafficking and/or processing of RNA
  • involved in the regulation of protein export from nucleus
  • functionally related to microtubule dynamics and axon development
  • may have a role in the developing nervous system and the adult brain
  • phosphorylates the spliceosome assembly factor
  • SF1
  • essential for neurite outgrowth in cortical neurons, stimulates 3' untranslated region-dependent local translation in neuritic projections, a component of the molecular device modulating translation in RNA-transporting granules and may participate in RNA splicing
  • CELLULAR PROCESS cell cycle, progression
    nucleotide
    PHYSIOLOGICAL PROCESS cellular trafficking transport , neurogenesis
    text regulation of protein export from nucleus
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule nucleotide,
  • ATP
  • protein
  • stathmin
  • CDKN1B/p27Kip1
  • KIF3A, NonO, and eEF1A
  • UHMK1, also called KIS, double-phosphorylates both serines of the SPSP motif of SP1
  • cell & other
    REGULATION
    induced by serum growth factors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia (SCZD9)
    Variant & Polymorphism three SNPs (rs7513662 P=0.0007, rs6427680 P=0.0252, rs6694863 P=0.015) and several haplotypes showed association (eg HAP-A, HAP-B, HAP-C permutation P=0.00005)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • a clear reduction in total neuritic length and the
  • neurite count per cell after KIS knockdown by siRNA