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FLASH GENE
Symbol ASIP contributors: mct - updated : 03-02-2016
HGNC name agouti signaling protein, nonagouti homolog (mouse)
HGNC id 745
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
five disulfide bonds
HOMOLOGY
interspecies homolog to murine agouti (A) signaling protein
Homologene
FAMILY agouti family
CATEGORY signaling hormone
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • melanocortin receptor (MC1R) antagonist
  • playing a role in hair or skin pigmentation and regulating the lipid metabolism within adipocytes
  • pharmacological antagonist of alpha-melanocyte-stimulating hormone
  • play a role in neuroendocrine aspects of melanocortin action
  • have a functional role in regulating lipid metabolism in adipocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS behavioral , homeostasis
    text
  • energy homeostasis
  • appetite
  • PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein antagonizing MC4R
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to skin sensitivity to sun
  • to cutaneous melanoma (CM)
  • to facial pigmented spots during aging
  • Variant & Polymorphism other
  • pol 8818A -> G associated with dark hair and brown eyes
  • haplotype increasing the risk of cutaneous melanoma (CM)
  • genetic variations in ASIP, contribute to the acquired amount of facial pigmented spots during aging, through pathways independent of the basal melanin production
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS