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FLASH GENE
Symbol BRWD3 contributors: mct - updated : 09-10-2017
HGNC name bromodomain and WD repeat domain containing 3
HGNC id 17342
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight N-terminal WD40 repeats, that may facilitate the formation of protein complexes
  • two C-terminal bromodomains
  • HOMOLOGY
    interspecies homolog to murine Brwd3
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION acts as a positive regulator of the JAK/STAT
    signaling pathway
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRX93
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
          --low  
    downregulated in a majority of 22 BCLL cases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • increased in breast cancer plasma, confirming for its diagnostic value as serum marker
  • EMBO Rep. 2015 Apr;16(4):528-38. doi: 10.15252/embr.201439092. Epub 2015 Feb 9. Erratum in: EMBO Rep. 2016 Jul;17(7):1082. Liu, Kuei-Yan [corrected to Liu, Kwei-Yan].
    Therapy target
    ANIMAL & CELL MODELS
    in vivo analysis demonstrated that disrupted Drosophila BRWD3 and overexpressed Ptp61F function as suppressors of leukemia-like blood cell tumors