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FLASH GENE
Symbol MPC2 contributors: mct - updated : 10-04-2013
HGNC name mitochondrial pyruvate carrier 2
HGNC id 24515
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to yeast Fmp43 protein
homolog to murine Brp44
Homologene
FAMILY PF0041 (0-44) family
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,membrane
text
  • MPC1 and MPC2 associate to form an ~150-kilodalton complex in the inner mitochondrial membrane
    • basic FUNCTION
  • essential for mitochondrial pyruvate transport (
  • MPC1 and MPC2 form an essential part of the mitochondrial pyruvate carrier
  • MPC1 and MPC2 are obligatory components of facilitated pyruvate transport in mammalian cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MPC1 and MPC2 associate to form an ~150-kilodalton complex in the inner mitochondrial membrane
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to schizophrenia
    • Variant & Polymorphism SNP
  • SNP rs10489202 located in intron 1 of BRP44, is associated to schizophrenia
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS