basic FUNCTION
| negative regulator of mitogen activated protein (MAP) kinase family |
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playing a role necessary and sufficient for TP53 -induced apoptosis and growth suppression |
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inducible, nuclear-specific, dual-specificity mitogen-activated protein (MAP) kinase phosphatase that is a transcription target of TP53 in signaling apoptosis and growth suppression |
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involved in ERK2 dephosphorylation, requiring association of its N-terminal domain with ERK2 that results in catalytic activation of the phosphatase |
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having a crucial role in E2F1-directed apoptosis |
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involved in stimulus-specific, and phosphatase-specific mechanism of MAPK1 regulation in the nucleus |
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with DUSP1, and DUSP10 are crucial players in the regulation of immune responses, but other members of the family, like the ERK-specific DUSP6, play a major role in development |