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FLASH GENE
Symbol ZFP57 contributors: mct/npt - updated : 21-08-2013
HGNC name zinc finger protein 57 homolog (mouse)
HGNC id 18791
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal Kruppel-associated box (KRAB) domain
  • seven zinc fingers
  • HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    basic FUNCTION
  • zinc-finger transcription factor expressed in early development
  • may be having a role in maintenance of imprinted DNA methylation during the earliest multicellular stages of development
  • methylated TGCCGC hexanucleotide is the motif that is recognized by ZFP57 in all imprinting control regions (ICRs) and in several tens of additional loci, several of which are at least ZFP57-dependently methylated in ES cells
  • may recruit DNA methyltransferases to its target regions to maintain DNA methylation imprint, and this interaction is likely facilitated by TRIM28
  • recognizes the methylated CpG within the TGCCGC element
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • ZFP57 and its cofactor TRIM28 are associated with DNMTs and hemimethylated DNA-binding UHRF1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HILS , TNDM2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS