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FLASH GENE
Symbol EIF4E3 contributors: mct - updated : 06-05-2015
HGNC name eukaryotic translation initiation factor 4E family member 3
HGNC id 31837
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure
  • retain the eIF4E fold of a central curved beta-sheet consisting of seven antiparallel beta-strands flanked by three alpha helices at its convex surface
  • HOMOLOGY
    interspecies homolog to murine Eif4e3 (94.7pc)
    homolog to rattus Eif4e3 (94.7pc)
    Homologene
    FAMILY
  • eukaryotic initiation factor 4E family
  • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • EIF4E3 is in the nucleus and cytoplasm
  • basic FUNCTION
  • translational initiation factor that interacts with the 5' CAP strucutre of mRNA and recruits mRNA to the ribosome
  • may act as an inhibitor of EIF4E activity
  • is an inhibitor, rather than a promoter, of both target transcript expression and oncogenic transformation
  • EIF4E3 repressed the expression of a pool of target mRNAs common with EIF4E
  • represses target expression and oncogenic transformation, in direct contrast to EIF4E, which stimulates these processes
  • is, unexpectedly, a tumor suppressor and that it requires its atypical mode of cap recognition for this function
  • EIF4E, EIF4E2, and EIF4E3, are essential for translation initiation
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the EIF4F complex
  • INTERACTION
    DNA
    RNA
  • recognizes and bins to the 7-methylguanosine containing mRNA cap during an early step in the initiation of protein synthesis
  • small molecule
    protein
  • interacting with EIF4G1
  • MKNK1, MKNK2, can modulate oncogenic translation by regulating EIF4E-EIF4E3 levels and activity in diffuse large B-cell lymphoma (DLBCL)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS