basic FUNCTION
| translational initiation factor that interacts with the 5' CAP strucutre of mRNA and recruits mRNA to the ribosome |
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may act as an inhibitor of EIF4E activity |
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is an inhibitor, rather than a promoter, of both target transcript expression and oncogenic transformation |
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EIF4E3 repressed the expression of a pool of target mRNAs common with EIF4E |
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represses target expression and oncogenic transformation, in direct contrast to EIF4E, which stimulates these processes |
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is, unexpectedly, a tumor suppressor and that it requires its atypical mode of cap recognition for this function |
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EIF4E, EIF4E2, and EIF4E3, are essential for translation initiation |