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FLASH GENE

Symbol

ATAD2

contributors: mct - updated : 05-03-2011

HGNC name	ATPase family, AAA domain containing 2
HGNC id	30123

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	AAA type ATPase domain
	a bromodomain

HOMOLOGY

interspecies

homolog to murine Atad2

intraspecies

homolog to ATAD2B

Homologene

FAMILY

AAA ATPase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,nucleus

basic FUNCTION	estrogen-regulated AAA+ ATPase coactivator for ESR1, and required for coregulator occupancy and chromatin modification
	controls chromatin dynamics, genome transcriptional activities and apoptotic cell response
	functions as a global regulator of chromatin structure and function
	crucial for assembly of chromatin-modifying complexes and proliferation of hormone-responsive cancer cells
	acts as a pioneer factor in E2F-dependent gene activation and this novel mechanism involving ATAD2 bromodomain may contribute to cancer cell proliferation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATB binding

protein	target of estrogen in human breast cancer cells, and controls the estrogen-dependent expression of several ESR1 target genes
	binds the MYC oncogene and stimulates its transcriptional activity
	links the E2F and MYC pathways and contributes to the development of aggressive cancer through the enhancement of MYC-dependent transcription
	direct target of oncogene AIB1/ACTR/SRC-3 and a transcriptional coregulator for estrogen and androgen receptors

cell & other

associates with chromosomes at late mitosis, and its occupancy at E2F targets peaks at the G(1)-to-S transition

REGULATION

Other

pRB-E2F pathway regulates ATAD2 expression, which is limiting for the entry into the S phase of the cell cycle

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   up-regulated in breast, uterus, colon, ovary, and stomach tumors tumoral     --over   in several cancer, and its high expression is a strong predictor of rapid mortality in lung and breast cancers tumoral     --over   in somatic cells, by acting on basic properties of chromatin, may contribute to malignant transformation

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     intrinsic properties of its two domains, AAA-ATPase and bromodomain, could provide a basis for the development of therapeutic strategies specifically targeting ATAD2 in cancer cancer reproductive breast prognostic marker and a therapeutic target for triple-negative cancers

ANIMAL & CELL MODELS