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FLASH GENE
Symbol ZNF133 contributors: npt/ - updated : 04-10-2004
HGNC name zinc finger protein 133
HGNC id 12917
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal KRAB domain
  • a several zinc finger motifs, C2H2 type, Krüppel-like
  • 14 contiguous zinc finger motifs, interacting with protein inhibitor of activated STAT1 (PIAS1) (Lee 2007)
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • zinc finger protein family
  • KRAB subfamily
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in transcriptional regulation as a repressor
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with PIAS1 (PIAS1 enhanced the transcriptional repression activity of ZNF133 through the zinc finger motifs) (Lee 2007)
  • cell & other
    REGULATION
    Other regulated by both the KRAB domain and the zinc finger motifs, and that the repressive effect by zinc finger motifs is mediated by PIAS1 (Lee 2007)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS