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FLASH GENE
Symbol TRIM55 contributors: KTN/npt - updated : 03-02-2009
HGNC name tripartite motif-containing 55
HGNC id 14215
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RING-type zinc finger
  • a B-box type-2 zinc finger
  • a coiled-coil domain
  • a COS (C-terminal subgroup one signature) domain
  • mono polymer homomer , heteromer , oligo
    HOMOLOGY
    interspecies ortholog to murine Trim55 (85.8 pc)
    ortholog to rattus Trim55 (85.3 pc)
    Homologene
    FAMILY
  • C-II TRIM family
  • MURF subfamily
  • RBCC family
  • CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may regulate gene expression and protein turnover in muscle cells
  • acting as a transient adaptor
  • playing a regulatory role in the assembly of sarcomeres
  • acting as an ubiquitin-protein ligase
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS development
    text
  • muscle development
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
  • homooligomer
  • heterooligomer (probable)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with titin/TTN
  • myosins
  • SQSTM1
  • NBR1
  • TRIM63
  • TRIM54
  • cell & other
    REGULATION
    Other downregulated during cardiac development
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS