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FLASH GENE
Symbol LRRC8D contributors: mct - updated : 20-01-2022
HGNC name leucine rich repeat containing 8 family, member D
HGNC id 16992
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 16 extracellular leucine-rich repeats
  • four transmembrane regions
  • secondary structure
  • LRRC8D homo-hexamer structure displays a two-fold symmetric arrangement, and together with a structure-based electrophysiological analysis, revealed two key features
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • may be implicated in proliferation and activation of lymphocytes and monocytes
  • is a mammalian protein required for the import of the antibiotic blasticidin S
  • LRRC8D-containing VRACs are crucial for cell volume regulation by an important organic osmolyte and may influence cisplatin/carboplatin responsiveness of tumors
  • was crucial for the translocation of overall neutral compounds like myo-inositol, taurine and GABA, and sustained the transport of positively charged lysine
  • LRRC8A/D-containing permeability pathway appears to dominate the release of uncharged osmolytes, while an alternative channel (or channels) is composed of LRRC8A/C/D/E and responsible for the loss of charged molecules
  • LRRC8D/VRAC anion channels enhance beta-cell glucose sensing and insulin secretion
  • pore-forming component of the volume-regulated anion channel (VRAC)
  • LRRC8A and LRRC8D have been implicated in the proliferation, migration, death, and multidrug resistance of cancer cells through their involvement in various signal pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • LRRC8A/LRRC8C and LRRC8A/LRRC8D heteromers were strongly inhibited by oxidation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LRRC8D interacts with LRRC8A, LRRC8B, and LRRC8C
  • combinatory expression of LRRC8A with LRRC8D and LRRC8C is essential for Volume-sensitive outwardly rectifying anion channels (VSOR) activity, whereas none of LRRC8 family members is involved in acid-sensitive outwardly rectifying anion channels (ASOR) activity
  • LRRC8D inhibits cGAMP transport
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS