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FLASH GENE
Symbol INTS12 contributors: - updated : 04-04-2006
HGNC name integrator complex subunit 12
HGNC id 25067
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one PHD-type zinc finger
mono polymer complex
HOMOLOGY
interspecies ortholog to murine Phf22
homolog to chicken PHF22
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • is recruited to the U1 and U2 snRNA genes and mediates the snRNA's 3' end processing
  • the integrator complex mediates RNA polymerase-II-dependent transcription
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the integrator complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein stably associated with RNAPII
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS