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FLASH GENE
Symbol PAQR3 contributors: mct - updated : 09-02-2012
HGNC name progestin and adipoQ receptor family member III
HGNC id 30130
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminus interacts with G beta and tethers G betagamma to the Golgi apparatus , facing the cytosol
  • multiple sequences are responsible for its localization at the Golgi apparatus and RAF1 interaction
  • first discovered Golgi protein with seven transmembrane domains
  • HOMOLOGY
    interspecies ortholog to murine Paqr3
    ortholog to rattus Paqr3_predicted
    Homologene
    FAMILY
  • PAQR (Progestin and AdipoQ Receptors) family
  • CATEGORY regulatory , receptor membrane
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • integral to membrane
  • located at the Golgi apparatus
  • basic FUNCTION
  • acts as a spatial regulator of Raf kinase by sequestering Raf to the Golgi apparatus, thereby antagonizing the mitogen-activated protein kinase (Raf/MEK/ERK) signaling cascade
  • may play a suppressive role in melanoma that harbors an oncogenic BRAF mutation via its antagonistic action on BRAF
  • functions as a spatial regulator of RAF1 kinase by sequestrating RAF1 to the Golgi
  • inhibits G betagamma- and ligand-mediated AKT phosphorylation that is enhanced in cells with downregulation of PAQR3
  • can modulate GPCR signaling through sequestering G betagamma to the Golgi apparatus and thereby attenuating the functions of G betagamma
  • negative regulator of mitogen-activated protein kinase (Raf/MEK/ERK) signaling, by sequestration of Raf kinase to the Golgi apparatus, in angiogenesis and clear-cell renal cell carcinoma
  • likely implicated in the development of clear-cell renal cell carcinoma through its regulation on angiogenesis
  • spatial regulator of Raf kinase, in VEGF-mediated signaling and angiogenesis
  • can inhibit HIF1A- and hypoxia-stimulated VEGF expression and such inhibition is mediated by the Raf/MEK/ERK signaling pathway
  • promotes SCAP/SREBF complex formation, potentiates SREBF processing and enhances lipid synthesis
  • regulates cholesterol homeostasis by anchoring SCAP/SREBF to the Golgi and disruption of such function reduces cholesterol biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between PAQR3 and adiponectin may help explain the antiproliferative properties of adiponectin
  • PAQR3 interacts with SCAP and SREBF and tethers them to the Golgi
  • cell & other
    REGULATION
    repressed by adiponectin that functions as an agonist of PAQR3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in clinical clear-cell renal cell carcinoma, with an inverse correlation with VEGF expression level
    constitutional   deletion    
    can enhance VEGF-induced angiogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS