| basic FUNCTION
| acts as a spatial regulator of Raf kinase by sequestering Raf to the Golgi apparatus, thereby antagonizing the mitogen-activated protein kinase (Raf/MEK/ERK) signaling cascade |
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may play a suppressive role in melanoma that harbors an oncogenic BRAF mutation via its antagonistic action on BRAF  |
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functions as a spatial regulator of RAF1 kinase by sequestrating RAF1 to the Golgi |
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inhibits G betagamma- and ligand-mediated AKT phosphorylation that is enhanced in cells with downregulation of PAQR3 |
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can modulate GPCR signaling through sequestering G betagamma to the Golgi apparatus and thereby attenuating the functions of G betagamma |
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negative regulator of mitogen-activated protein kinase (Raf/MEK/ERK) signaling, by sequestration of Raf kinase to the Golgi apparatus, in angiogenesis and clear-cell renal cell carcinoma |
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likely implicated in the development of clear-cell renal cell carcinoma through its regulation on angiogenesis |
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spatial regulator of Raf kinase, in VEGF-mediated signaling and angiogenesis |
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can inhibit HIF1A- and hypoxia-stimulated VEGF expression and such inhibition is mediated by the Raf/MEK/ERK signaling pathway |
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promotes SCAP/SREBF complex formation, potentiates SREBF processing and enhances lipid synthesis |
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regulates cholesterol homeostasis by anchoring SCAP/SREBF to the Golgi and disruption of such function reduces cholesterol biosynthesis |
