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FLASH GENE
Symbol RNF169 contributors: mct - updated : 03-11-2014
HGNC name ring finger protein 169
HGNC id 26961
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RING-type zinc finger domain
  • two LR motifs (LRMs), and LRM2 binds to nucleosomes, the substrates of RNF168
  • HOMOLOGY
    intraspecies paralog to RNF168
    Homologene
    FAMILY peptidase C19 family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • having ubiquitin-protein ligase activity
  • E3 ubiquitin ligase, accumulated in DSB repair foci through recognition of RNF168-catalyzed ubiquitylation products by its motif interacting with ubiquitin domain
  • dispensable for chromatin ubiquitylation and ubiquitin-dependent accumulation of repair factors at DSB sites
  • is a negative regulator of the DNA damage signaling cascade
  • is a component in DNA damage signal transduction and adds to the complexity of regulatory ubiquitylation in genome stability maintenance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • functions in a noncanonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization
  • interacted with ubiquitin structures and relocalized to DSBs in an RNF8/RNF168-dependent manner
  • RNF169 antagonizes potentially RNF168 functions at DSBs
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS