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FLASH GENE
Symbol AAMDC contributors: mct - updated : 11-06-2021
HGNC name adipogenesis associated Mth938 domain containing
HGNC id 30205
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • regulates the expression of several metabolic enzymes involved in the one-carbon folate and methionine cycles, and lipid metabolism
  • AAMDC-RABGAP1L complex could play a role in the regulation of vesicle trafficking, potentially altering the recycling of small G proteins and thus remodeling the cancer signaling network
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • AAMDC can interact with the RabGTPase-activating protein RABGAP1L, and AAMDC, RABGAP1L, and RAB7A colocalize in endolysosomes
  • cell & other
    REGULATION
    Other is post-transcriptionally regulated through alternative polyadenylation (APA) and microRNAs
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS