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FLASH GENE
Symbol HRNR contributors: mct - updated : 16-05-2018
HGNC name hornerin
HGNC id 20846
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two EF-hand calcium-binding domains
  • HOMOLOGY
    interspecies homolog to murine Hrnr
    homolog to drosophila prc
    Homologene
    FAMILY
  • S100-fused protein family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus
    text
  • keratohyalin granules in the granular cells of the epidermis
  • in the epidermis, HRNR was detected at the periphery of keratohyalin granules in the upper granular layer and at the corneocyte periphery in the whole cornified layer
  • basic FUNCTION
  • having a function similar to but distinct from that of filaggrin in cornification
  • dispensable for acquisition of thermotolerance and does not play a significant role in recovery or protection of cells from acute heat shock
  • is a component of cornified cell envelopes of human epidermis
  • potential role in inflammatory/immune response or proliferation
  • role in the control of mammary cell function and breast cancer
  • shares numerous features with filaggrin, a key contributor to the epidermal barrier functions
  • is a regulator of tumor vascularity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • CAPN1 may be involved in the proteolytic processing of HRNR, because CAPN1 was co-located with HRNR in the cytoplasm of granular keratinocytes
  • cell & other
    REGULATION
    induced by DNA lesions or heat-shock stress
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    expressed in psoriatic skin
    tumoral     --over  
    on pancreatic tumor endothelium in a vascular endothelial growth factor (VEGF)-independent manner
    Susceptibility to atopic dermatitis (AD)
    Variant & Polymorphism SNP associated to atopic dermatitis (AD)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS