basic FUNCTION
| having a function similar to but distinct from that of filaggrin in cornification |
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dispensable for acquisition of thermotolerance and does not play a significant role in recovery or protection of cells from acute heat shock |
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is a component of cornified cell envelopes of human epidermis |
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potential role in inflammatory/immune response or proliferation |
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role in the control of mammary cell function and breast cancer |
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shares numerous features with filaggrin, a key contributor to the epidermal barrier functions |
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is a regulator of tumor vascularity |