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FLASH GENE
Symbol PLA2R1 contributors: mct/npt - updated : 12-06-2009
HGNC name phospholipase A2 receptor 1, 180kDa
HGNC id 9042
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • an N terminal cysteine domain
  • a fibronectin-like type II domain
  • a shorter secreted form with the same binding properties
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Mrc2 (73.2pc)
    homolog to murine Pla2g1br (73.8pc)
    Homologene
    FAMILY
    CATEGORY enzyme , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text integral to plasma membrane
    basic FUNCTION
  • acting as a phospholipase receptor
  • presence on neutrophils and having role in elastase release and adhesion (Silliman 2002)
  • regulates a variety of biological responses elicited by secretory phospholipase A2s (sPLA2s) (Hanasaki 2004)
  • potential new tumour suppressor gene crucial in the induction of cellular senescence through the activation of the TP53 pathway (Augert 2009)
  • genetically modifying the expression has an important impact on the senescence of primary cells (Augert 2009)
  • could regulate senescence by controlling the production of cytokines, as is able to regulate cytokines (cytokines are involved in senescence outcome) and is a new crucial regulator of senescence in human primary cells (Augert 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • sugar
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to premature coronary artery disease in the absence of hypercholesterolemia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS