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FLASH GENE
Symbol CERS6 contributors: mct - updated : 03-01-2008
HGNC name LAG1 homolog, ceramide synthase 6
HGNC id 23826
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an homeobox DNA-binding domain
  • a TLC (TRAM/LAG1/CLN8) domain
  • HOMOLOGY
    interspecies ortholog to murine Lass6
    intraspecies homolog to LASS5
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    text
  • integral to membrane
  • basic FUNCTION
  • may be involved in sphingolipid synthesis or its regulation
  • key enzymes generating ceramide
  • playing a role in cancer differentiation and early embryonic development
  • regulates synthesis of a specific subset of ceramides and displays a unique substrate specificity profile for chain length and/or saturation in fatty acid acyl-CoA
  • prosurvival role of CERS6/C(16)-ceramide involved in the protection against ER-stress-induced apoptosis and induction of HNSCC tumor growth
  • important role for the CERS genes CERS2, CERS6) in breast cancer etiology or diagnosis
  • interplay among the CERS proteins (CERS2, CERS5, CERS6) in a stress stimulus-, cell type- and subcellular compartment-specific manner
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • lipid biosynthesis
  • a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by MAPK10 in cerebral ischemia/reperfusion
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS