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FLASH GENE
Symbol DPH3 contributors: mct/npt - updated : 18-10-2005
HGNC name DPH3, KTI11 homolog (S. cerevisiae)
HGNC id 27717
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DPH-type zinc finger
  • HOMOLOGY
    interspecies ortholog to murine Zcsl2
    Homologene
    FAMILY
  • DPH3 family
  • zinc finger protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • being essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphteria toxin and by pseudomonas exotoxin A
  • playing a possible role in the secretion process indicated by the increase of extracellular release of proteoglycans produced by the DPH3 down-regulation
  • stimulating binding of SERGEF to SEC5
  • acting in diphthamide biosynthesis (Webb 2008)
  • in addition to having a role in diphthamide biosynthesis, is also involved in modulating the functions of the Elongator complex in yeast (Liu 2006)
  • having a physiological importance in development (Liu 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text negative regulation of protein secretion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • SERGEF
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS