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FLASH GENE
Symbol REEP1 contributors: mct/npt - updated : 05-04-2016
HGNC name receptor accessory protein 1
HGNC id 25786
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminus of REEP1 is necessary for proper targeting to and/or retention in the ER
  • two transmembrane domains, the first of which may function as a signal peptide
  • common domain REEP5/DP, and HVA22
  • HOMOLOGY
    Homologene
    FAMILY
  • DP1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • is present at the ER-mitochondria interface, and it contains subdomains for mitochondrial as well as ER localization
  • basic FUNCTION
  • may enhance the cell surface expression of odorant receptors
  • involved in chaperone-like activities
  • co-overexpression of ATL1 and REEP1, generates large Lipid droplets (LDs)
  • membrane shaping adapter protein that modulate specific G protein-coupled receptor trafficking by affecting ER cargo capacity
  • role of REEP1 in lipid droplet biology
  • conserved role of REEP1 in promoting stress resistance and preventing the formation of Tau aggregates
  • facilitates ER-mitochondria interactions, a function diminished by disease-associated mutations
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/olfaction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with odorant receptor proteins
  • with ATL1 and SPAST, interact within the tubular ER membrane in corticospinal neurons to coordinate ER shaping and microtubule dynamics
  • ZFYVE27 interact with other hereditary spastic paraplegia-related proteins including myelin proteolipid protein 1 (SPG2), atlastin-1 (SPG3A), REEP1, REEP5 (similar to REEP1), KIF5A, KIF5B, KIF5C
  • VIMP can interact with CKAP4 and SNX5, it does not interact with MT-binding ER proteins (such as REEP1) that shape the tubular smooth ER
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG31 , DHMN5B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS