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FLASH GENE
Symbol NOXA1 contributors: mct - updated : 25-01-2011
HGNC name NADPH oxidase activator 1
HGNC id 10668
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four N-terminal tetratrico-peptide repeats, and PRR domain
  • a conserved "activation domain" motif
  • a PB1 domain
  • a C-terminal SH3 domain
  • HOMOLOGY
    intraspecies homolog to p67-phox
    Homologene
    FAMILY
  • NCF2/NOXA1 family
  • NOX family of NADPH oxidases
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • participating in activation of superoxide-producing NADPH oxidases
  • mediating the binding of other regulatory proteins during activation of the phagocyte oxidase, and its translocation to the membrane is triggered upon cell activation by hyperphosphorylation
  • acts in conjunction with Nox organizer 1 (NOXO1) to regulate reactive oxygen species (ROS) production by the NADPH oxidase NOX1
  • likely a key player that links oxidized low-density lipoprotein with the activation of endothelial NAD(P)H oxidase
  • with NOXO1, having a role, as well as the binding of Rac1 GTPase, for NOX1 activity
  • functional homolog of NCF2 in VSMCs (vascular smooth muscle cell) that regulates redox signaling and VSMC phenotype
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • assembly of the NOX1 oxidase complex can be regulated through reversible protein-protein interactions
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PKA-phosphorylated NOXA1 is a new binding partner of 14-3-3 protein(s)
  • interaction between NOXO1 and NOXA1 is significantly different from that between the homologous proteins of the phagocytic oxidase, suggesting that there are important functional differences between the two systems
  • SH3PXD2B, SH3PXD2A directly bind to NOXA1, and the integrity of the N-terminal PRR of NOXA1 is essential for this direct interaction with the Tks proteins
  • cell & other
    REGULATION
    Other phosphorylation of NOXA1 is a part of the feedback mechanism that functions through activation of Rac with a net outcome of negative modulation of NOX1 activity
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    bloodcoagulation 
    potential for modulation of NOXA1 expression as a viable approach for the treatment of vascular diseases
    ANIMAL & CELL MODELS
    NoxA1 expression was significantly increased in aortas and atherosclerotic lesions of ApoE(-/-) mice compared with age-matched wild-type mice