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FLASH GENE
Symbol LEO1 contributors: mct - updated : 17-04-2014
HGNC name Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
HGNC id 30401
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Leo1-like domain, a senescence-associated domain that accelerates the senescence of 2BS fibroblasts
  • mono polymer heteromer , dimer , complex
    HOMOLOGY
    Homologene
    FAMILY
  • LEO1 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • potential requirement for LEO1 in the development of the heart and neural crest cell populations
  • LEO1, but not RTF1, is necessary for the complex to bind RNA
  • cells lacking LEO1 have reduced PAF1C recruitment as well as decreased levels of histone H3 and trimethylated H3 Lys within transcribed chromatin
  • RTF1, CDC73, and LEO1 have all been shown to play a role in recruitment of PAF1C to chromatin at active genes
  • CELLULAR PROCESS cell life, senescence
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with CDC73, PAF1, SH2BP1, RTF1
  • PAF1 and LEO1 subunits form a tightly associated heterodimer through antiparallel beta-sheet interactions 8)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with beta-catenin in the Wnt pathway (Bralten 2010)
  • LEO1 is a novel and important mediator of PTP4A3 oncogenic activities in Acute Myeloid Leukemia (AML)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with SLC12A1 in glioma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS