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FLASH GENE
Symbol TENM2 contributors: mct - updated : 14-09-2018
HGNC name teneurin transmembrane protein 2
HGNC id 29943
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ectodomains containing eight EGF-like repeats, two of which have unpaired cysteine residues that mediate covalent homodimerization of the molecule
  • distal part of the C terminus, containing 6 NHL and 26 YD repeats
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Odz2
    homolog to the Drosophila pair-rule gene ten-m/odz
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    basic FUNCTION
  • membrane-bound transcription regulator
  • large cell surface glycoprotein with a single TMR found in all animal species
  • play a role in development, neurite outgrowth, axon guidance, neuronal connectivity, and synaptogenesis
  • requirement for Ten-m2 in the establishment of ipsilateral projections, and thus the generation of binocular circuits, critical for mammalian visual function
  • TENM2 deficiency in human adipocyte precursors leads to induction of brown adipocyte marker genes upon adipogenic differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TENM2 deficiency induces UCP1 expression in differentiating human fat cells
  • an alternatively spliced region within the beta propeller acts as a switch to regulate trans-cellular adhesion of TENM2 to latrophilin (ADGRL1), a transmembrane receptor known to mediate critical functions in the central nervous system
  • TENM2, directly interacts with ADGRL1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS