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FLASH GENE
Symbol B4GALNT3 contributors: SGE - updated : 27-07-2010
HGNC name beta-1,4-N-acetyl-galactosaminyl transferase 3
HGNC id 24137
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal transmembrane domain
  • four potential N-glycosylation sites
  • a DXH sequence thought to participate in divalent cation binding
  • a C-terminal WGGED motif (Sato 2003)
  • HOMOLOGY
    interspecies homolog to murine B4galnt3 (84.7pc)
    homolog to rattus B4galnt3 (83.5pc)
    Homologene
    FAMILY
  • chondroitin N- acetylgalactosaminyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • could transfer GalNAc residues, producing N, N'-diacetylgalactosediamine structures at least in N-glycans and probably in both N- and O-glycans
  • up-regulation of B4GALNT3 may contribute to the malignant behavior of colon cancer cells (Huang 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpressed in colon cancer cell line, enhancing cell-extracellular matrix adhesion, migration, anchorage-independent growth and invasion (Huang 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS