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FLASH GENE
Symbol AHCTF1 contributors: mct - updated : 28-12-2016
HGNC name AT hook containing transcription factor 1
HGNC id 24618
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal &
  • 946;-propeller domain
  • 1 A.T hook DNA-binding domain
  • a central alpha-helical domain,
  • has conserved structural domains that are essential for its fundamental roles in NPC assembly and chromosome segregation
  • a C-terminal disordered region
  • HOMOLOGY
    interspecies ortholog to murine Elys
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,kinetochore
    intracellular,nuclear envelope,pore
    text localized to both the nuclear pores and nuclear interior during interphase, and to the kinetochore in mitosis
    basic FUNCTION
  • may play a role in early development being critical for the survival of inner cells of the blastocyst
  • dual nucleoporin/kinetochore protein required for nuclear pore assembly at the nucleus and proper cell division
  • NUP37 and AHCTF1 are stable architectural nucleoporins that occur, independent of one another
  • minimal essential function of nucleosomes in nuclear pore complexes (NPCs) formation is to recruit RCC1 and AHCTF1
  • plays a critical role in post-mitotic nuclear pore complexes (NPCs) reassembly through recruitment of the NUP107-160 subcomplex, and is required for correct segregation of mitotic chromosomes
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of both the nuclear pore and kinetochore as well as being intranuclear
  • KPNB1 forms a high-molecular-weight complex with both AHCTF1 and the NUP107-160 complex in cytosol
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • capture of AT-rich chromatin by AHCTF1 recruits POM121 and NDC1 to initiate nuclear pore assembly
  • nucleoporin AHCTF1, which is crucial for postmitotic NPC formation, is essential for recruiting the LBR to the chromosomal noncore region
  • is a RanGTP target that functions throughout the cell cycle
  • docks the catalytic subunit of protein phosphatase 1 (PPP1CC) to direct kinetochore disassembly-dependent chromosome segregation during oocyte meiosis I and nuclear assembly during the transition from M phase to interphase
  • depletion of AHCTF1 promoted LBR phosphorylation at the residues known to be phosphorylated by cyclin-dependent kinase (CDK) and serine/arginine protein kinases 1 and 2 (SRPK1 and SRPK2, respectively)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • conditional inactivation of the Elys locus in the developing mouse intestinal epithelium led to a reversible delay in growth in juvenile mice that was associated with epithelial architecture distortion and crypt cell apoptosis