basic FUNCTION
| SAMD9/SAMD9L are myeloid tumor suppressors (Asou 2009) |
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RNA interference of SAMD9L expression enhanced the migratory phenotype of activated T cells treated with IFN-beta compared with controls (Pappas 2009) |
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SAMD9 and SAMD9L have also recently been shown to play key roles in the innate immune responses to stimuli such as viral infection |
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haploinsufficiency of SAMD9L and/or SAMD9 gene(s) contributes to myeloid transformation |
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role of SAMD9L in the regulation of cell proliferation |
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has a role in cell proliferation, most likely as a tumor suppressor |
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is likely one of the crucial genes in the development of sporadic myelodysplastic syndromes and myeloid leukemias, including those characterized by deletions of chromosome 7q |