Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ACTR5 contributors: npt/mct/pgu - updated : 14-02-2009
HGNC name ARP5 actin-related protein 5 homolog (yeast)
HGNC id 14671
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Actr5
Homologene
FAMILY
  • actin family
  • ARP5 subfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • both ACTR5 and ACTR8 localize to the nuclei of interphase cells
  • during mitosis, ACTR5 is excluded from chromatin
  • basic FUNCTION
  • functioning as an integral component of a multisubunit ATP-dependent chromatin remodeling complex
  • functioning as an integral component of a multisubunit ATP-dependent chromatin remodeling complex
  • contributes to a wide variety of chromatin-dependent nuclear transactions, including transcription, DNA repair and DNA replication
  • ACTR8 is required for the recruitment, and ACTR5 is required for the DNA repair functions of the INO80 complex
  • is a key regulator of MYOCD activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ATP-dependent chromatin remodeling complex
  • part of INO80 complex containing three actin-related proteins (ARPs), of which ACTR5 and ACTR8 are specific to the INO80 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ACTR5 bound to a DNA binding domain of SRF via its C-terminal sequence and prevented the association of the MYOCD-SRF complex with the promoter regions of smooth muscle genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS