Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CDK2AP2 contributors: mct - updated : 11-02-2016
HGNC name CDK2-associated protein 2
HGNC id 30833
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Cdk2ap2
Homologene
FAMILY DOC1 family
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • tumor suppressor activity
  • CDK2AP2 under normal conditions has a biphasic expression, suggesting regulatory roles in early-versus-late stem cell differentiation
  • CDK2AP2 overexpression inhibited G1/S phase transition, DNA replication and suppressed CDK2 activity
  • antitumor effects of CDK2AP2 may be mediated by negatively regulating G1 phase progression and G1/S transition through inhibiting CDK2 expression and activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • negative regulator of CDK2 activity
  • CDK2AP1 has two putative binding partners: CDK2AP2 and CDK2
  • CDK2AP2 associated with CDK2 and inhibited CDK2 activation by obstructing its association with cyclin E and A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS