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FLASH GENE
Symbol E2F7 contributors: mct - updated : 15-03-2022
HGNC name E2F transcription factor 7
HGNC id 23820
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two DNA-binding domains (DBDs)
  • HOMOLOGY
    Homologene
    FAMILY E2F family of transcription factors
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    text
  • localises to the perinucleolar region (PMID;
  • basic FUNCTION
  • playing an essential role in the regulation of cell cycle progression
  • regulating the expression of genes involved in cell cycle, DNA replication, DNA repair, and mitosis
  • E2F7 and E2F8 contain two DNA-binding domains (DBDs) and act as repressors
  • synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer
  • E2F7 is a key player in DNA damage-dependent transcriptional regulation of cell-cycle genes
  • is an atypical E2F family member that acts as a transcriptional repressor of E2F target genes, and thereby contributes to cell cycle arrest
  • E2F7 and E2F8 act as tumor suppressors via transcriptional repression of genes involved in S-phase entry and progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binds to the E2F DNA binding consensus site independently of DP co-factors
    RNA
    small molecule
    protein
  • unique repressor of a subset of E2F target genes whose products are required for cell cycle progression
  • TP53-dependent transcriptional up-regulation of its target, E2F7, leads to repression of relevant gene expression
  • E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1A
  • E2F7 restricts homologous recombination through the transcriptional repression of RAD51
  • CCNF-dependent degradation of E2F7 is critical for DNA repair and G2-phase progression
  • mechanistically, SAPCD2 could directly bind to cytoplasmic E2F7 but not E2F1, alter the subcellular distribution of E2F7 and regulate E2F activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    predicts poor prognosis in human patients with gliomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might act as an independent prognostic factor of gliomas
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    might constitute a potential therapeutic target for gliomas
    ANIMAL & CELL MODELS