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FLASH GENE
Symbol LPCAT3 contributors: mct - updated : 01-09-2012
HGNC name lysophosphatidylcholine acyltransferase 3
HGNC id 30244
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
asparaginase domain
HOMOLOGY
interspecies ortholog to murine Grcc3f
ortholog to Drosophila "Nessy"
intraspecies homolog to LPT1
Homologene
FAMILY membrane-bound acyltransferase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • involved in mesoderm and endoderm development
  • primarily responsible for hepatic LPCAT activity
  • plays a critical role in phosphatidylcholine remodeling in metabolic tissues and provide an invaluable tool for future investigations on how phosphatidylcholine remodeling may potentially impact glucose and lipid homeostasis
  • primarily responsible for hepatic LPCAT activity
  • LPCAT3 and MBOAT7 are implicated in arachidonate recycling, thus regulating free arachidonic acid levels and leukotriene synthesis in neutrophils
  • lysophospholipid acyltransferase acting preferentially on lysoPC (LPC), lysoPS (LPS) and lysoPE (LPE)
  • necessary role for lysophospholipid esterification in maintaining cellular function and structure
  • signal-regulated enzyme that is centrally implicated in limiting free arachidonic acid levels in activated cells
  • LPCAT3 and MBOAT7 are implicated in arachidonate recycling, thus regulating free arachidonic acid levels and leukotriene synthesis in neutrophils
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Hox proteins Ultrabithorax, Antennapedia and AbdominalA
  • cell & other
    REGULATION
    repressed by Hox proteins Ultrabithorax, Antennapedia and AbdominalA
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS