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FLASH GENE
Symbol SPRN contributors: mct - updated : 17-10-2007
HGNC name shadow of prion protein homolog (zebrafish)
HGNC id 16871
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a highly conserved N-terminal signal sequence
  • Arg-rich basic region containing up to six tetrarepeats of consensus XXRG (where X is G, A or S)
  • a hydrophobic region of 20 residues with strong homology to PrP
  • a C-terminal peptide predicted to be a signal sequence for glycophosphotidylinositol (GPI)-anchor attachment, and a functionally conserved and ancient activity domain contributing to neuroprotection
  • HOMOLOGY
    interspecies homolog to PRNP
    Homologene
    FAMILY prion protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    text GPI anchored
    basic FUNCTION
  • playing a role in GTP binding
  • potential modulator for the biological actions of normal and abnormal PRNP
  • has neuroprotective properties
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein may interact either directly or indirectly with PRNP or its ligand (Campbell 2008)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    or low in prion infections
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS