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FLASH GENE
Symbol IPMK contributors: mct - updated : 28-06-2013
HGNC name inositol polyphosphate multikinase
HGNC id 20739
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to rattus Ipmk
ortholog to murine Ipmk
Homologene
FAMILY
  • inositol phosphokinase (IPK) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • nucleocytoplasmic shuttling protein, whose nuclear export is mediated by classical nuclear export receptor XPO1
  • basic FUNCTION
  • inositol phosphate kinase with a broad substrate specificity
  • having a preference for inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate
  • may regulate the level of Ins(1,4,5,6)P4 and have an effect on chloride channel regulation
  • the most catalytically diverse member of this family with critical roles in nuclear functions including mRNA export, transcriptional regulation, and chromatin remodeling
  • regulates glucose signaling to AMPK in a pathway whereby glucose activates phosphorylation of IPMK at tyrosine 174 enabling the enzyme to bind to AMPK and regulate its activation
  • role for the hypothalamic IPMK signaling in the control of AMPK and central energy homeostasis
  • multifunctional protein in cellular signal transduction, namely, a multispecific inositol phosphate kinase, phosphatidylinositol 3-kinase, and a scaffold within the MTOR-raptor complex
  • is a versatile player in insulin-, nutrient-, and energy-mediated metabolism signaling networks
  • acts potentially as a transcriptional coactivator for TP53 and it is an integral part of the TP53 transcriptional complex facilitating cell death
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • possesses both inositol phosphate kinase and lipid kinase activities, regulates amino acid signaling to MTOR
  • physiologically binds AMPK, with binding enhanced by glucose treatment
  • DVL3 translocates IPMK to the cell membrane in response to Wnt
  • stimulated TP53-mediated transcription by binding to TP53 and enhancing its acetylation by the acetyltransferase EP300 independently of its inositol phosphate and lipid kinase activities
  • cell & other
    REGULATION
    repressed by CSNK2A1 (CSNK2A1 binds endogenous IPMK and phosphorylates it at serine 284)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetemetabolic syndrom 
    Agents that control IPMK functions may provide novel therapeutics in metabolic syndromes such as obesity and diabetes
    diabetetype 2 
    Substances that block IPMK-mTORC1 binding may afford therapeutic benefit in nutrient amino acid-regulated conditions such as obesity
    obesity  
    Substances that block IPMK-mTORC1 binding may afford therapeutic benefit in nutrient amino acid-regulated conditions such as diabetes
    ANIMAL & CELL MODELS