basic FUNCTION
| putative adhesion molecule |
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essential for maintenance of the complex cytoarchitecture of the glomerular filtration barrier within the kidney |
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playing a necessary role for polarization and directed migration |
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regulates actin cytoskeletal organization at cell peripheries, thereby modulating cell contacts and polarity |
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atypical cadherin induced robustly after arterial injury, has significant effects on mammalian vascular smooth muscle cell (VSMC) growth and migration |
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FAT1 and ATRS (ATN1 and RERE), act in concert after vascular injury but show further that distinct Atr isoforms have disparate effects on vascular smooth muscle cells directional migration |
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may be involved in the migration and invasion mechanisms of oral squamous cell carcinoma and, therefore, it could be an important target for the development of new therapeutic strategies |
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uncleaved FAT1 could promote altered signaling, and the novel products of alternate processing provide a dominant negative function in melanoma |
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regulate diverse biological functions as cell proliferation and planar cell polarity, and also to affect wound healing |
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novel signaling mechanism mediated by FAT1 in regulating the activity of PDCD4 and thereby the key transcription factor AP1, which then affects known mediators of neoplasia and inflammation |
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FAT1 and FAT4 suppress tumor growth via activation of Hippo signaling, whereas FAT1 promotes tumor migration via induction of actin polymerization |
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FAT1 is tumor suppressive or oncogenic in a context& |
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8209;dependent manner |
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is a critical determinant of muscle form, misregulation of which associates with FSHD |
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acts to control neurite outgrowth, also driving cells towards terminal differentiation via inhibitory effects on proliferation |
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is a new upstream Hippo element regulating early stages of differentiation in neuronal cells |
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FAT1 and FAT4 binding coordinates likely distinct pathways at apical junctions to regulate neural progenitor proliferation, neural tube closure and apical constriction |
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atypical FAT1 cadherin acts as a molecular 'brake' on mitochondrial respiration that regulates vascular smooth muscle cell (SMC) proliferation after arterial injury |
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FAT1 controls likely mitochondrial activity to restrain cell growth during the reparative, proliferative state induced by vascular injury |