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FLASH GENE
Symbol PKN3 contributors: mct - updated : 13-06-2017
HGNC name protein kinase N3
HGNC id 17999
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region of PKN1, PKN2, PKN3 plays a role in their regulation, and also contains three Rho-binding domains (HR1a, HR1b, and HR1c)
  • HOMOLOGY
    interspecies ortholog to murine Pkn3
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • acting as a protein serine/threonine kinase
  • PKN1 and PKN3 phosphorylate serine residues in sequence contexts that have an arginine residue in position -3
  • appears to play a pivotal role in maintaining endothelial cell morphology, cell-cell junctions and motility
  • PKN3 plays critical roles in angiogenesis and tumor metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • physically interacts with Rho-family GTPases, and preferentially with RHOC, a known mediator of tumor invasion and metastasis in epithelial cancers
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    impairs actin and adherens junctions dynamics and attenuates endothelial cell activation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    PKN3-RHOC complex represents an attractive therapeutic target in late-stage malignancies
    ANIMAL & CELL MODELS