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FLASH GENE
Symbol PIBF1 contributors: mct - updated : 12-03-2018
HGNC name progesterone immunomodulatory binding factor 1
HGNC id 23352
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • N-terminal signal sequence
  • a nuclear localization signal
  • a leucine zipper motif
  • a basic zipper sequence
  • a PEST sequence
  • an endoplasmic reticulum membrane retention signal
  • several potential N-glycosylation and phosphorylation sites
  • secondary structure alpha-helical protein
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • component of pericentriolar satellites, and is present both in the centrosome and in the cytoplasm, but is transiently concentrated at the centrosome once cells enter mitosis
  • basic FUNCTION
  • mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect
  • is a molecule with inhibitory effects on cell-mediated immune reactions
  • is crucial for maintaining the integrity of spindle poles during mitosis
  • likely PIBF1 affects the expression of leptin and its receptor, and PIBF1 expression is inversely related to trophoblast invasiveness
  • is a centriolar satellite protein that is critical for spindle pole integrity in mitotic cells
  • KISS1, KISS1R play a major role in trophoblast invasion, and progesterone-induced blocking factor (PIBF1) is needed for maintaining pregnancy
  • is an immunomodulatory protein with known role in the regulation of the immune response in the reproductive system
  • vital regulatory cascade involving IL33, decidual B cells and PIBF1 in safeguarding term pregnancy
  • promotes likely proliferation, migration, and invasion of human glioblastoma cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PIBF1 acts on lymphocytes in pregnancy to induce a type 1 to type 2 cytokine shift by upregulating the production of type 2 cytokines
  • physically interacts with PCM1 at centriolar satellites, and this interaction is essential for centrosomal accumulation of the centriolar satellites and eventually for primary cilia formation
  • PIBF1 is also required for BBS4 loading on centriolar satellites and its localization in primary cilia
  • PIBF1 expression by B cells is induced by the mucosal alarmin IL33
  • cell & other
    REGULATION
    induced by progesterone
    ASSOCIATED DISORDERS
    corresponding disease(s) JBTS33
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    decreased KISS1 and PIBF1 expressions in trophoblasts and deciduas are associated with recurrent spontaneous abortion (RSA)
    constitutional     --low  
    spindle pole fragmentation was the most characteristic phenotype in PIBF1-depleted cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • for treatment of reccurent aborting (failing in women with recurrent abortion)
  • Marker
  • pregnancy termination can be predicted by lower than normal pregnancy PIBF1 values within 5 days before labor and can contribute to the diagnosis of preterm birth
  • preterm birth may be predictable at 24-28 gestational week by lower than normal pregnancy PIBF1 values and measurement of PIBF1 concentration in biological fluids at that time may be of importance in clinical practice
  • Therapy target
    ANIMAL & CELL MODELS
  • B cell deficiency in mice resulted in a lower uterine level of active progesterone-induced blocking factor 1 (Pibf1), and therapeutic administration of Pibf1 mitigated spontaneous preterm labor (PTL) and uterine inflammation in B cell-deficient mice