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FLASH GENE
Symbol TMEM165 contributors: mct - updated : 20-08-2012
HGNC name transmembrane protein 165
HGNC id 30760
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal signal sequence
  • 6 predicted transmembrane domains
  • HOMOLOGY
    interspecies ortholog to murine Tparl
    Homologene
    FAMILY
  • UPF0016 family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    text
  • integral to membrane
  • perinuclear Golgi-like distribution, present in the late Golgi (trans) rather than in the early Golgi (cis and median)
  • basic FUNCTION
  • important role for TMEM165 in Golgi glycosylation and Golgi morphology maintenance
  • is potentially responsible for passive proton leakage within the secretory pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2K
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS