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FLASH GENE
Symbol KCNK18 contributors: mct - updated : 16-03-2011
HGNC name potassium channel, subfamily K, member 18
HGNC id 19439
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two pore-forming domains
  • four transmembrane domains
  • an NFAT-like docking site that is present at its intracellular loop
  • HOMOLOGY
    interspecies homolog to murine Kcnk18
    homolog to C. elegans twk-6
    Homologene
    FAMILY double-pore domain K+ channel family
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral to membrane
    basic FUNCTION
  • acting as a potassium channel
  • may set the resting membrane potential of cells in the spinal cord
  • key role in controlling neuronal resting membrane potential and neuronal excitability
  • target of volatile anesthetics and potential role in mediating the effects of inhaled anesthetics in the central nervous system
  • activation of both KCNK18 and NFAT via Ca(2+)-calcineurin-NFAT/KCNK18 pathway could modulate the transcription of new genes in addition to regulating several aspects of T-cell function
  • role in the pathogenesis of typical migraine with aura
  • plays an key part in the excitability of neurons that are crucial to migraine pathogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • potassium ion transport
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • calcineurin has been found to interact with KCNK18 via specific NFAT-like docking site
  • cell & other
    REGULATION
    activated by reversibly activated by the calcium/calmodulin-dependent protein phosphatase, calcineurin
    by volatile anesthetics such as halothane
    highly activated by Ca(2+), calcineurin, acetylcholine, and histamine which induce hypertrophy
    inhibited by immunosuppressants, such as cyclosporin A and FK506
    Other regulated by the calcium/calmodulin-dependent phosphatase calcineurin and 14-3-3 adaptor proteins
    phosphorylation of KCNK18 at two distinct regulatory regions, the 14-3-3 binding site (Ser-264) and the cluster of three adjacent serine residues (Ser-274, Ser-276, and Ser-279), are responsible for channel inhibition
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyepilepsy 
    potential therapeutic target in familial migraine with aura
    ANIMAL & CELL MODELS