basic FUNCTION
| mediating down-regulation of protein synthesis in response to various stress conditions by the phosphorylation of EIF2S1 at Ser-48 and Ser-51 |
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inhibiting protein synthesis at the level of initiation |
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essential for regulating globin translation in iron deficiency and in beta-thalassemia |
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playing a critical role in the regulation of protein synthesis by heme iron |
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negative regulation of hemoglobin biosynthesis |
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activated under various cytoplasmic stresses in reticulocytes leading to inhibition of initiation of protein synthesis |
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normally modulates the basal hepatic ER stress tone ( |
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functions in response to heme shortage in reticulocytes and aids in the maintenance of a heme:globin ratio of 1:1 |
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EIF2AK1-mediated process plays a central role in the cellular infection cycle of the Gram-positive pathogen Listeria |