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FLASH GENE
Symbol ASAP3 contributors: mct/pgu - updated : 23-02-2013
HGNC name ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
HGNC id 14987
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an Arf GTPase-activating protein (ArfGAP) domain
  • two ankyrin repeats
  • one pleckstrin homology domain (PH) required for efficient catalytic activity of the protein
  • a BAR domain
  • a proline-rich
  • SH3 domains
  • HOMOLOGY
    interspecies ortholog to murine Ddefl1
    intraspecies homolog to DDEF/ASAP1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text associated with focal adhesions and circular dorsal ruffles
    basic FUNCTION
  • promoting proliferation of cells
  • regulation of GTPase activity
  • Arf GTPase-activating protein implicated in the pathogenesis of hepatocellular carcinoma, and that may regulate cell migration associated with the invasion of normal tissue by cancer cells
  • having functions nonredundant with ASAP1 to control cell movement and may have a role in cancer cell invasion
  • present in cell structures required for cell migration and invasion, such as focal adhesions, invadopodias, and podosomes, and are involved in endocytosis and cytoskeletal remodeling 0)
  • involvement in carcinogenesis and metastasis highlights the importance of the presented structure in general and the Ca2+-binding pocket in particular as it may give clues for designing inhibitors for therapeutic applications
  • novel function for ASAP3 in the regulation of cell migration through controlling ITGB1 dynamics
  • important regulator in cancer cell migration/invasion and actin-based cytoskeletal remodeling
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    carboxylic acid metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ARF6 (has a phosphatidylinositol 4,5-bisphosphate-dependent GAP activity specific for ARF6)
  • ARF6 GTPase-activating protein, essential for EGF-induced cell migration
  • regulates ITGB1 dynamics during EGF-stimulated cell migration by interaction with GRB2
  • ASAP3 linked with ACTG1 in the regulation of cytoskeletal maintenance and cell motility
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    up-regulated in hepatocellular carcinomas (HCCs)
    constitutional     --low  
    reduced actin stress fibers
    Susceptibility
    Variant & Polymorphism
    Candidate gene for new strategies for diagnosis and treatment of HCC
    Marker
    Therapy target
    ANIMAL & CELL MODELS