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FLASH GENE
Symbol CCAR1 contributors: mct - updated : 26-12-2018
HGNC name cell division cycle and apoptosis regulator 1
HGNC id 24236
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus,nucleoplasm
text
  • NEUROG3 and CCAR1 are co-localized in the nucleus
  • basic FUNCTION
  • key mediator of signaling by CD437 or adriamycin allows for delineation of pathways that, in turn, may prove beneficial for design and targeting of novel antitumor agents
  • apoptosis inducer, that regulates apoptosis signaling by diverse agents, including adriamycin and growth factors
  • promotes apoptosis by activating MAPK14 and caspase-9, and is involved in apoptosis signaling by epidermal growth factor receptor
  • regulates expression of key proliferation-inducing genes
  • also functions as a TP53 coactivator, suggesting a broader role in transcriptional regulation
  • function as a transcriptional coactivator for nuclear receptors, also interacts with beta-catenin and enhances the ability of beta-catenin to activate expression of transiently transfected reporter genes
  • perinuclear phospho-protein, regulating signaling by adriamycin, steroids, or growth factors (
  • important co-activator for estrogen-induced gene expression and estrogen-dependent growth of breast cancer cells
  • can serve as a co-activator for different classes of transcription factors to maintain the balance of proliferation, apoptosis, and differentiation
  • potential role in PTH signaling and bone anabolic action
  • positively regulates adipocyte differentiation through the glucocorticoid signaling pathway
  • CCAR2 and CCAR1 are largely disordered proteins that have evolved from one common ancestor
  • plays a dynamic role in regulation of cell growth and apoptosis by serving as a cofactor of steroid/thyroid nuclear receptors, CTNNB1, and TP53 in a variety of cell types including different cancer cells
  • CCAR1 contributes to carcinogenesis in gastric cancer and is required for the survival of gastric cancer cells
  • CCAR1 is a novel transcriptional cofactor for NR1I3
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • novel component of Wnt/beta-catenin signaling that plays an important role in transcriptional regulation by beta-catenin
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • 14-3-3 protein as well as causes reduced expression of cell cycle regulatory genes including c-Myc and cyclin B1
  • microtubule dependent association of AKAP9 and CCAR1 with RNA stress granules
  • binds with signal transducer TAZ and over-expression of TAZ inhibits apoptosis by CCAR1
  • transcriptional coactivator for nuclear receptors, also interacts with NEUROG3
  • NDN exerts its pro-survival activity by counteracting the action of the pro-apoptotic protein Cell Cycle Apoptosis Regulatory Protein (CCAR1/CARP1)
  • can act as an enhancer-dependent coactivator of NR1I3 1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may serve as a diagnostic marker in gastric cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may represent a novel target for therapeutic intervention in cancers involving aberrantly activated Wnt/beta-catenin signaling
    cancer  
    SRSF5-CCAR1 axis may be valuable targets for cancer therapeutics
    cancerdigestivestomach
    potential therapeutic target in gastric cancer
    ANIMAL & CELL MODELS