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FLASH GENE
Symbol TSPAN8 contributors: mct - updated : 28-10-2010
HGNC name tetraspanin 8
HGNC id 11855
PROTEIN
PHYSICAL PROPERTIES other
STRUCTURE
motifs/domains
  • four potential hydrophobic transmembrane domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Tm4sf3
    ortholog to rattus Tm4sf3
    homolog to xenopus tm4sf3-prov
    Homologene
    FAMILY
  • transmembrane 4 superfamily
  • tetraspanin (TM4SF) family
  • CATEGORY regulatory , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • mediating signal transduction events that play a role in the regulation of cell development, activation, growth and motility
  • might be involved in esophageal carcinoma metastasis )
  • contributed to a selective recruitment of proteins and mRNA into exosomes, including VCAM1 and ITGA4, which were implicated in exosome-endothelial cells binding and endothelial cellsinternalization
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • complexing with integrins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    all forms of cirrhosis
    tumoral     --over  
    in esophageal carcinomas
    Susceptibility
  • to schizophrenia
  • to bipolar disorder (BPD)
  • Variant & Polymorphism SNP
  • nsSNP rs3763978 was associated with schizophrenia
  • upstream transcriptional control region however, rs4500567 is associated with BPD
  • Candidate gene
    Marker
    Therapy target
  • with ADAM12L, might be potential targets of esophageal carcinoma for anti-metastasis therapy
  • ANIMAL & CELL MODELS