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FLASH GENE
Symbol SPSB1 contributors: mct - updated : 28-12-2006
HGNC name splA/ryanodine receptor domain and SOCS box containing 1
HGNC id 30628
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a central SPRY domain
  • a C-terminal SOCS box
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • suppressor of cytokine signaling (SOCS) protein family
  • SPRY (repeats in splA and RyR) domain-containing SOCS box protein (SSB) subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • may play an important role in enhancing the HGF-induced Erk-Elk-1-SRE pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with MET(bound to MET tyrosine kinase domain through its SPRY domain, in both the absence and the presence of HGF)
    cell & other
    REGULATION
    Other in response to HGF stimulation, became phosphorylated at tyrosine residue 31
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS