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FLASH GENE
Symbol TAOK1 contributors: mct/npt - updated : 27-08-2019
HGNC name TAO kinase 1
HGNC id 29259
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal header domain
  • a catalytic domain
  • a protein kinase [amino acids 28281] domain
  • a coiled-coil motifs 1 [amino acids 458651] and 2
  • a substrate-binding domain
  • a spacer region
  • a tail domain
  • HOMOLOGY
    interspecies ortholog to murine Taok1
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • STE20 subfamily
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    text
  • TAOK1 and TAOK2 localize to the cytoplasm and centrosomes respectively during mitosis
  • basic FUNCTION
  • activated MEK3
  • involved in the regulation of the p38-containing stress-responsive MAP kinase pathway
  • induced apoptotic morphological changes that include cell contraction, membrane blebbing, and apoptotic body formation
  • activating the polarity -inducing kinase MARK1
  • microtubule affinity-regulating kinase kinase, is also an important regulator of mitotic progression, required for both chromosome congression and checkpoint-induced anaphase delay (Draviam 2007)
  • dual functions in regulating microtubule dynamics and checkpoint signalling may help to coordinate the establishment and monitoring of correct congression of chromosomes, thereby protecting genomic stability in cells (Draviam 2007)
  • the three-way interaction between SPRED1, TAOK1, and TESK1 represents a pathway that links regulation of both the microtubule- and F-actin cytoskeleton (Johne 2008)
  • TAO kinases are potential tumor suppressor genes
  • controls various biological phenomena, including microtubule dynamics, animal behavior, and brain development
  • is required for ensuring the normal congression of chromosomes
  • is involved in the development of IL17A-related autoimmune disorders
  • induce microtubule instability via activation of microtubule affinity-regulating kinase (MARK) and phosphorylation of microtubule-associated proteins, including tau
  • plays a role in the establishment of neuronal polarity, neuronal differentiation, and early brain development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • form a subgroup of sterile 20 (STE20)-like kinases that regulate different cytoskeletal processes
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • two new interaction partners, the regulatory Sprouty-related protein with EVH-1 domain1 (SPRED1) and the testis-specific protein kinase (TESK1)(Johne 2008)
  • interacts with the checkpoint kinase BUB1B and promotes enrichment of the checkpoint protein MAD2 at sites of defective attachment, providing evidence for a regulatory step that precedes the proposed MAD2-MAD1 dependent checkpoint-signal amplification step (Draviam 2007)
  • TAOK1 functions as a negative regulator of IL17A-mediated signal transduction and inflammation
  • TAOK1 interacts with IL-17 receptor A (IL17RA) independent of its kinase activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NDDMH
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    decreased in the colons of ulcerative colitis patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    may offer novel therapeutic targets suitable for drug inhibition and the potential treatment of breast cancers, where supernumerary centrosomes occur
    ANIMAL & CELL MODELS