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FLASH GENE
Symbol CLMP contributors: mct - updated : 29-05-2019
HGNC name CXADR like membrane protein
HGNC id 24039
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • V-type (variable) domain
  • C2-type (constant) Ig domain
  • a single transmembrane segment
  • a cytoplasmic tail
  • extracellular immunoglobulin (Ig)-like domain(s)
  • cytoplasmic juxtamembrane domain
  • C-terminal PZD-binding domain
  • HOMOLOGY
    Homologene
    FAMILY
  • CTX gene family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
        intracellular
    intracellular,cytoplasm
    text
  • type I transmembrane protein
  • co-localized with the tight junction markers ZO-1 and occludin
  • basic FUNCTION
  • may be the critical adhesion molecule in adipocyte differentiation and development of obesity
  • acting as a receptor for group b coxsackieviruses and subgroup c of adenoviruses
  • probably involved in transepithelial migration of polymorphonuclear leukocytes (pmn) through adhesive interactions with AMICA1 located in the plasma membrane of pmn
  • plays a role in intestinal development, but does not play a key role in cellular processes involved in intestinal epithelial development
  • is a novel cell-cell adhesion molecule
  • may be important role in cell adhesion events during ovulation and luteal formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the epithelial apical junction complex that is essential for the tight junction integrity
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TNF-mediated mRNA degradation of the CLMP gene is controlled by TTP (tristetraprolin) through the JNK signalling cascade
  • absence of CLMP caused a severe reduction of GJA1, GJC1 in smooth muscle cells of the intestine and of GJA1 in the ureter
  • cell & other
    REGULATION
    Other mRNA expression was progressively up-regulated during differentiation
    ASSOCIATED DISORDERS
    corresponding disease(s) CSBS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    caused functional obstructions in the intestinal tract and ureter by impaired peristaltic contractions most likely due to a lack of gap-junctional communication between smooth muscle cell
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS