Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol EFTUD2 contributors: mct - updated : 18-02-2016
HGNC name elongation factor Tu GTP binding domain containing 2
HGNC id 30858
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Snrp116
ortholog to C.elegans eft-1
ortholog to xenopus snrp116
Homologene
FAMILY
  • GTP-binding elongation factor family
  • EF-G/EF-2 subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • required for pre-mRNA splicing
  • acting as a translational elongation factor
  • protein of the spliceosome complex
  • participation of EFTUD2 as a novel innate immune regulator, suggesting a potentially targetable antiviral pathway
  • pre-mRNA splicing factor PRPF8 is a crucial component of the U5 snRNP, and together with EFTUD2 and SNRNP200, it forms a central module of the spliceosome
  • functions likely in RNA splicing during neural development
  • CELLULAR PROCESS nucleotide, RNA splicing
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the U5 snRNP complex
  • spliceosome complex
  • pre-mRNA splicing factor PRPF8 is a crucial component of the U5 snRNP, and together with EFTUD2 and SNRNP200, it forms a central module of the spliceosome
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • mRNA splicing regulator EFTUD2, controls the alternate splicing of the MYD88 innate immunity signaling adaptor to modulate the extent of the innate immune response
  • SNW1 interacted with the N-terminus of EFTUD2 as well as two independent regions in the C-terminus of SNRNP200
  • exerts its antiviral activity mainly through governing its downstream regulators DDX58 and IFIH1 by gene splicing to activate IRF3 and induce classical ISG expression independent of the JAT-STAT signaling pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MFDM
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS