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FLASH GENE
Symbol PLCB4 contributors: mct - updated : 19-05-2012
HGNC name phospholipase C, beta 4
HGNC id 9059
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • phosphatidylinositol-specific phospholipase C family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the hydrolysis of phosphatidylinositol 4,5 biphosphate to generate diacylglycerol and inositol 1,4,5 triphosphate
  • mediating a wide variety of cellular stimuli
  • signaling of phospholipase C beta 4 is not essential for the survival of midbrain dopaminergic neurons
  • in the medial septum is involved in controlling cholinergic theta oscillation and cholinergic theta rhythm plays a critical role in suppressing anxiety
  • significant contribution of PSMD3-CSF3 and PLCB4 loci to the regulation of neutrophil count
  • PLCB4 and GNAI3 are core signaling molecules of the endothelin-1-distal-less homeobox 5 and 6 (EDN1-DLX5/DLX6) pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ACDS2
    related resource Retinal Information Network
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • PLCbeta4-deficient mice is a potential animal model for absence seizures