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FLASH GENE
Symbol APIP contributors: mct - updated : 25-01-2017
HGNC name APAF1 interacting protein
HGNC id 17581
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region of APIP that is missing in the short isoform is required for activity
  • HOMOLOGY
    interspecies ortholog to chicken APIP (86.1pc)
    ortholog to murine Apip (93.8pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • functioning to inhibit muscle ischemic damage by binding to APAF1 in the APAF1/caspase-9 apoptosis pathway
  • involvement of APIP in the methionine salvage pathway, which plays a key role in many biological functions like cancer, apoptosis, microbial proliferation and inflammation
  • inhibit two main types of programmed cell death, apoptosis and pyroptosis, and was recently found to be associated with cancers and inflammatory diseases
  • act as a 5-methylthioribulose-1-phosphate dehydratase, in the methionine salvage pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the CARD of APAF1 in competition with caspase-9
  • plays an essential role in ERBB3 signaling as a positive regulator for tumorigenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    of APIP and UACA in non-small cell lung carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS